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An overview of ozanimod as a therapeutic option for adults with moderate-to-severe active ulcerative colitis

Introduction: Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal tract involving a dysregulated immune response. Sphingosine-1-phosphate (S1P) is involved in immune cell regulation. S1P-receptor 什麼是最低存款金額 Expert Option? modulators, such as ozanimod, inhibit lymphocyte migration and have therapeutic potential in UC.

Areas covered: Ozanimod is the first S1P-receptor modulator approved for the treatment of UC. It acts as a functional antagonist, causing internalization of S1P receptors on T-cells. Lymphocyte egress from lymph nodes is inhibited, and migration to sites of active inflammation is curtailed. There are several S1P-receptor subtypes, present in various organs, which inform understanding of ozanimod's side-effect profile including bradycardia and macular edema. In this review, the authors discuss the mechanism of action, pharmacokinetics, clinical efficacy, and safety profile of ozanimod in the treatment of patients with moderate-to-severe UC.

什麼是最低存款金額 Expert Option? Expert opinion: The S1P-receptor modulator ozanimod is an oral small molecule with a rapid onset of action and a novel therapeutic mechanism in the treatment of UC. It is an effective treatment both in bio-naïve and bio-exposed patients. Although the safety profile of ozanimod looks favorable, more long-term data are needed. Further studies are required to compare ozanimod to currently available therapies to best define its positioning in UC treatment algorithms.

Keywords: Inflammatory bowel disease; ozanimod; small molecules; sphingosine-1-phosphate receptor modulators; ulcerative colitis.

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We help people live their lives to the fullest potential.

For more than 30 years, Beacon has changed the way people live with behavioral health conditions.

Today’s issues. Tomorrow’s innovations.

Learn how Beacon is leading the way for better care.

Expert insights at your fingertips

From clinical innovations to personal stories, our expert-driven blog Beacon Lens brings today’s behavioral health issues to the forefront.

One mission. Unlimited opportunities.

At Beacon, we’re driven by a mission to transform lives. Explore careers with us, and see what makes Beacon a great place to work.

For Members

Putting people at the center, 什麼是最低存款金額 Expert Option? we built a strong network of doctors, nurses, advocates, and mentors filling members' health needs.

For Brokers

We deliver a proven range of expert benefit solutions that are easy to administer and service, 什麼是最低存款金額 Expert Option? so you can focus on growing your business confidently.

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Our providers are vital to the services we offer our 40 million members so they can live their lives to the fullest potential.

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For 30 years, we have focused on behavioral health care and its natural extensions, such as EAPs and Work/Life services.什麼是最低存款金額 Expert Option?

Beacon Lens

Beacon Lens is our expert-driven blog that focuses on the most pressing issues facing behavioral health care today. Joining expertise, thought leadership, and personal first-hand stories from our colleagues, Beacon Lens presents a fresh, unique take on all things behavioral health.

Equity leadership summit brings passion – and policy recommendations – to the table

Beacon and Kennedy-Satcher: advancing behavioral health equity

Improving outcomes for people with opioid use disorder

Increasing access to behavioral health care through public / private partnerships